The Chromosome 7 Annotation Project
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Chromosome 7 Clinical table -- INVERSIONS (Malignant)

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# Unique IDKaryotypePhenotypeCytogenetic Break FromCytogenetic Break ToMolecular Breakpoint #1Molecular Breakpoint #2Pubmed IDPatient ID          Comments          
1 10360374_2_2 46, XX, inv(7)(p21q23), t(9;22)(q34;q11) [21]/ 46, XX, inv(7)(p23q23) [4] adult acute lymphocytic leukemia p23 q23     10360374 2 Mitelman Database, Reference No. 8064 Edit
2 8956866_19 46, XY, inv(7)(p22q32), del(13)(q12q14) [15]/ 46, XY [9] chronic lymphocytic leukemia p22 q32     8956866 19 Mitelman Database, Reference No. 6667 Edit
3 10360374_14_1 47, XY, inv(7)(p13p22), -7, der(9)del(9)(p13)t(9;22)(q34;q11), -19, +3mar [22] adult acute lymphocytic leukemia p22 p13     10360374 14 Mitelman Database, Reference No. 8064 Edit
4 12810258_5516 46, XY, inv(7)(p22q21) meningioma, grade I p22 q21     12810258 T5516 Mitelman Database, Reference No. 10151 Edit
5 10640979_36_4 46, XY, der(1)inv(1)(p21p?36.1)inv(1)(p?36.1p31), t(6;7)(p?23;q?23), del(7)(p12p12) [cp4]/ 46, Y, t(X;17)(q13;q21), t(2;6)(p21;q13), del(7)(q34), inv(7)(p22q11.2), t(15;17)(q10;q10), t(18;19)(q11.2;q13.3) [cp3] meningioma of the brain p22 q11.2     10640979 36 Mitelman Database, Reference No. 8428 Edit
6 1321916_29_1 41, Y, t(X;1)(p11;q21), i(1)(q10), der(3)t(3;13)(p12;q12), -4, -5, inv(7)(p22q11), -9, -10, -11, -13, add(16)(q11), +17, -18, +20/ 71-76, Y, t(X;1)(p11;q21)x2, +1, +2, t(3;13), -4, -5, +7, inv(7)x2, +8, add(8)(p11)x2, -9, -10, +12, -13, +16, add(16)x2, +17, -18, +19, +20, +21, +22, +2mar renal adenocarcinoma p22 q11     1321916 29 Mitelman Database, Reference No. 4577 Edit
7 14654949_41 46, XY, inv(7)(p15or22q11or22). ish inv(7)(p21q21.3) [15] T-cell acute lymphoblastic leukemia p21.3 p21     14654949 41   Edit
8 8527384_23_2 46, XX, der(7)del(7)(q21.3q31.3)inv(7)(p21q31.3) uterine leiomyoma p21 q31.3     8527384 23   Edit
9 8527384_16_2 46, XX, der(7)del(7)(q11.2q22)inv(7)(p21q32) uterine leiomyoma p21 q32     8527384 16   Edit
10 6944153_6 46, XY, inv(7)(p21q36) acute myeloblastic leukemia - M2 p21 q36     6944153 6 Mitelman Database, Reference No. 616 Edit
11 10360374_2_1 46, XX, inv(7)(p21q23), t(9;22)(q34;q11) [21]/ 46, XX, inv(7)(p23q23) [4] adult acute lymphocytic leukemia p21 q23     10360374 2 Mitelman Database, Reference No. 8064 Edit
12 3538996_LY1 46, XY, inv(7)(p2100q11.22) mat leukemia p21 q11.22     3538996 LY1 father and paternal half-brother had same inversion Edit
13 9973943 46, XY, inv(7)(p21q31) [15]/ 46, XY [10] [bone marrow] acute myeloblastic leukemia - M2 (de novo) p21 q31     9973943   Mitelman Database, Reference No. 7840 Edit
14 10686941_12 45, XY, add(1)(p34), add(4)(q25), inv(7)(p21q22), -11, der(22)t(11;22)(?;q11) [4]/ 44-46, idem, del(1)(q32)[4], der(9)t(1;9)(q12;q31)[11], add(16)(q12)[12], del(19)(q13)[7], -22[3], add(22)(p11)[3], +mar[6] [cp12] Wilms tumor p21 q22     10686941 12 Mitelman Database, Reference No. 8120 Edit
15 15674412_18 46, XY, inv(7)(p15q34) [20] T cell acute lymphoblastic leukemia p15.2 q34 RP11-1132K14 RP11-785K24/ RP11-701D14 15674412, 16673021, 17039236 18 [15674412, 16673021], 6 [17039236] partial deletion of the centromeric TCRβ probe in 96% of cells was observed; breakpoint at 7p15 is within a ~20kb segment located between HOXA5 and HOXA9; Mitelman Database Reference No. 10935 Edit
16 15774621_TL44 inv(7)(p15q34) or t(7;7)(p15;q34) T-cell acute lymphoblastic leukemia p15.2 q34 HOXA10 CTD-3092H9/ RP11-368I15 15774621, 17039236 TL44 [15774621], 12 [17039236] breakpoint at 7p15 lies in at 3-prime end HOXA10 Edit
17 15774621_TL45 46, XX, inv(7)(p15q34) [9] T-cell acute lymphoblastic leukemia p15.2 q34 HOXA10 CTD-3092H9/ RP11-368I15 15774621, 17039236 TL45 [15774621], 13 [17039236] breakpoint at 7p15 lies in at 3-prime end HOXA10 Edit
18 15774621_TL46 46, XY, inv(7)(p15q34) or t(7;7)(p15;q34) T-cell acute lymphoblastic leukemia p15.2 q34 RH80053 TRBD1/ TRBD2 15774621, 17039236 TL46 [15774621], 14 [17039236] breakpoint at 7p15 lies in at 3-prime end HOXA10; two breakpoints at 7q34 lie in TRBD1 and TRBD2 Edit
19 17039236_2 46, XX, add(6)(qter), inv(7)(p15q34) [20] T-cell acute lymphoblastic leukemia p15.2 q34 HOXA9 TRBJ2-7 17039236 2 breakpoint at 7p15 lies in intron 1A of HOXA9 Edit
20 8527384_7_3 46, XX, del(7)(q11.2q32), der(7)del(7)(q11.2)inv(7)(p15q11.2) uterine leiomyoma p15 q11.2     8527384 7   Edit
21 8527384_10_2 46, XX, der(7)del(7)(q21q31)inv(7)(p15q32) uterine leiomyoma p15 q32     8527384 10   Edit
22 6467179_39 48, XX, dup(1)(q23q32), t(2;19)(p15p23;q13), +3, inv(7)(p15q11), +18, del(19)(q13) peripheral B-cell lymphoma, NOS p15 q11.2     6467179 39 Mitelman Databaase, Reference No. 1090 Edit
23 10590047_11 34 <1n>, X, +1, +5, +6, inv(7)(p1?5q11.2), +8, +10, +11, +13, +14, +19, +21, +22/ 69 <3n>, XX, -X, +1, -2, -3, -4, +5, +6, inv(7)(p1?5q11.2), -9, +11, -12, +13, +14, -15, -16, -17, -18, +19, +20, +21, +22/ 46, XX acute lymphoblastic leukemia p15 q11.2     10590047 11 Mitelman Database, Reference No. 8391 Edit
24 1402666 46, XY, t(1;14)(p32;q11), inv(7)(p15q35) [11]/ 46, XY [28] T-cell acute lymphoblastic leukemia p15 q35 TRGJ2_INV_P TRBJ2-1_INV_D 1402666, 8412327 JU Mitelman Database, Reference No. 5161 Edit
25 7954324_14 46, XY, inv(7)(p15q32), i(9)(q10), i(17)(q10) [19]/ 46, XY [1] [at relapse] acute lymphoblastic leukemia p15 q32     7954324 14 Mitelman Database, Reference No. 5569 Edit
26 7954324_22 45, XY, del(4)(q27), del(5)(q11), inv(7)(p15q22), +8, del(12)(p12), i(13)(q10), -16, -17, del(17)(p11) [20] [at diagnosis] chronic myelomonocytic leukemia p15 q22     7954324, 9973943 22 [7954324] Mitelman Database, Reference No. 5569 Edit
27 15674412_15 46, XX, inv(7)(p15q34) [4] T cell acute lymphoblastic leukemia p15 q34 RP11-1132K14 TRBJ2-1 15674412, 16673021, 17039236 15 [15674412, 16673021], 9 [17039236] partial deletion of the centromeric TCRβ probe in 95% of cells was observed; breakpoint at 7p15 is within a ~20kb segment located between HOXA5 and HOXA9; Mitelman Database Reference No. 10935 Edit
28 15674412_16 46, XX, add(5)(q31), inv(7)(p15q34) [11]/ 46, XX [9] T cell acute lymphoblastic leukemia p15 q34 RP11-1132K14 TRBJ2-5 15674412, 16673021, 17039236 16 [15674412, 16673021], 8 [17039236] breakpoint at 7p15 is within a ~20kb segment located between HOXA5 and HOXA9; Mitelman Database Reference No. 10935 Edit
29 15674412_17 46, XY, inv(7)(p15q34) [20] T cell acute lymphoblastic leukemia p15 q34 RP11-1132K14 RP11-785K24/ RP11-701D14 15674412, 16673021, 17039236 17 [15674412, 16673021], 7 [17039236] breakpoint at 7p15 is within a ~20kb segment located between HOXA5 and HOXA9; Mitelman Database Reference No. 10935 Edit
30 15674412_19 47, XY, del(6)(q14), inv(7)(p15q34), del(9)(p21), +mar1 [4]/ 46, XY [6] T cell acute lymphoblastic leukemia p15 q34 RP11-1132K14 RP11-785K24/ RP11-701D14 15674412, 16673021, 17039236 19 [15674412, 16673021], 5 [17039236] breakpoint at 7p15 is within a ~20kb segment located between HOXA5 and HOXA9; Mitelman Database Reference No. 10935 Edit
31 17039236_3 47, XY, +11 [7]/ 47, XY, inv(7)(p15q34), +21 [4]/ 46, XY [1] T-cell acute lymphoblastic leukemia p15 q34     17039236 3 TCRβ-HOXA rearrangement (+) Edit
32 17039236_4 46, XX, inv(7)(p15q34) del(9)(p12p24) [29] T-cell acute lymphoblastic leukemia p15 q34     17039236 4 TCRβ-HOXA rearrangement (+) Edit
33 16673021_21 46, XY, inv(7)(p15q34) or t(7;7)(p15;q34) [20] T-cell acute lymphoblastic leukemia p15 q34 RP1-167F23/ RP5-1103I5 RP11-1220K2/ RP11-556I13 16673021 21   Edit
34 16673021_22 47, XY, inv(7)(p15q34) or t(7;7)(p15;q34), +21 [20] T-cell acute lymphoblastic leukemia p15 q34 RP1-167F23/ RP5-1103I5 RP11-1220K2/ RP11-556I13 16673021 22   Edit
35 8527384_24_2 46, XX, der(7)del(7)(q21q31)inv(7)(p13q31) uterine leiomyoma p13 q31     8527384 24   Edit
36 2981155_Jha 45, X, -Y, der(3)t(3;14)(q12;q13), t(6;8)(q25;q22), inv(7)(p13q22), der(11)t(3;11)(q13;p15), -14, del(14)(q24), del(15)(q22), del(18)(q22), -19, +2mar/ 46, XY, del(2)(q23), add(3)(p?), add(4)(q?), del(9)(q22), -11, del(14), -15, +2mar Wilms tumor p13 q22     2981155 J. Ha Mitelman Database, Reference No. 1242 Edit
37 1878594_2 46, XY, inv(7)(p13q36) T cell acute lymphoblastic leukemia - L1 p13 q36     1878594 2 Mitelman Database, No. 4010 Edit
38 15588849_3_2 43-44, XY, dic(1;11)(q10;p11), der(3;19)(q10;q10), ins(4;?)(p14;?), del(6)(q15), i(6)(p10), +i(6)(q10), i(8)(q10), -11, -12, der(13;14)(q10;q10), -14, del(16)(q13), -17, -18, -19, -21, +der(?)t(?;1)(?;p22), +1-2mar [cp26]/ 45, Y, add(X)(q13), del(1)(p13), der(1)t(1;7)(q44;p15), t(2;9)(p11;q34), der(7)t(1;7)(p13;p13), der(13)t(13;14)(p11;q13), -14/ 45, XY, t(11;18)(q23;q21), t(12;16)(q11;p11), der(13)t(13;14)(p11;q13), -14 [8] [primary tumor]
40-44, XY, dic(1;11), der(3;19), ins(4;?), del(6), i(6)(p10), +i(6)(q10), i(8)(q10), -11, -12, der(13;14), -14, del(16), -17, -18, -19, -21, +der(?)t(?;1), +1-2mar [cp15]/ 46, X, t(Y;6)(q12;q21), t(1;7)(p36;p15), add(5)(p13), inv(7)(p13q36), t(8;9)(q22;q34), del(10)(p13), add(11)(p15), t(12;19)(q15;q13) [26] [local recurrence]
squamous cell carcinoma of the tongue p13 q36     15588849 3 Mitelman Database, Reference No. 10815 Edit
39 8418369_49_1 46, XY, der(5)t(5;7)(q12;q32), der(7)inv(7)(p13q32)t(5;7) acute lymphoblastic leukemia - L1 p13 q32     8418369 49 Mitelman Database, Reference No. 4743 Edit
40 8618441_16_1 43, X, dic(?Y;16)(q11;q13), -5, der(7)inv(7)(p11q22)del(7)(q22q32), -12, der(15)t(15;17?)(p11;q21), add(19)(p13), -20, +mar myelodysplastic syndrome - refactory anemia with excess of blasts p11 q22     8618441 16 Mitelman Database, Reference No. 6617 Edit
41 9552025_23 46, XY, inv(7)(p11q32), t(11;14)(p13;q11) acute lymphoblastic leukemia p11 q32     9552025 23 Mitelman Database, Reference No. 7566 Edit
42 Unpublished_99PB451 46, XY, add(1)(p32), del(5)(q?), inv(7), add(11)(q23), add(16)(p11), add(17)(p11) acute lymphoblastic leukemia pter qter   TCRB 99PB451 data unpublished Edit
43 10469450_166 46, XY, inv(7)(?), t(12;14)(q15;q24) [19] pulmonary chondroid hamartoma pter qter     10469450 166 Mitelman Database, Reference No. 8134 Edit
44 10451701_3 47, X, der(Y)t(Y;12)del(Y), der(5;15)t(5;7)(q11;q33)t(7;15)(q33;q13), der(7)t(7;15)(q22;q22.3)del(7)(q22q33)del(15)(q13q22.3), inv(7)x2, der(8)trp(8)ins(8;11)dup(11), + dup(8), +der(11)dup(11)t(8;11)trp(8), der(11)t(11;17), der(12)t(7;12)(q33;p11.2)del(12)(p11.2p13), +13, -15, -17 acute myeloblastic leukemia - M1 pter qter     10451701, 10398433 cell line GF-D8 [10451701], 6 [10398433] Mitelman Database, Reference No.7989 Edit
45 6609770_34 46, XX, inv(7)(p?) [100%] acute myeloid leukemia pter p10     6609770, 9973943 34 [6609770] Mitelman Database, Reference No. 1103 Edit
46 3965107_3 46, XX, inv(3)(q21q26), inv(7?), t(9;22)(q34;q11), del(15)(q22) [31] [blast crisis}
46, XX, inv(3)(p?q?), del(G) [20]/ 46, XX [3] [chronic phase]
chronic myeloid leukemia pter qter     3965107, 1581880 patient 3 [3965107], MPD-1 [1581880, Appendix 2]   Edit
47 23666224 45, XX, inv(3)(q21q26.2),- 7[19] acute myeloid leukemia, diabetes insipidus pter qter     23666224     Edit
48 6576176 46, XX, inv(7)(q22q11) pat acute lymphoblastic leukemia q11 q22     6576176, 6392555, 4040824, 3491573, 3546078, 7717416 reference 23 [6392555], ref 21 [3491573], reference 72 [7717416]   Edit
49 8309255 46, XY, t(3;17)(q21;q23), inv(7)(q11q22) acute myelomonocytic leukemia - M4 q11 q22     8309255, 9973943   Mitelman Database, Reference No. 5350 Edit
50 6583316_16 46, XY, inv(7)(q11q32) chronic myelomonocytic leukemia q11 q32     6583316, 9973943 16 [6583316] Mitelman Database, Reference No. 1056 Edit
51 9209470_II-1 46, XY, inv(7)(q11.2q22)c acute lymphoblastic leukemia q11.2 q22     9209470 II-1 (case 2) unaffected mother had the same karyotype Edit
52 9209470_III-4 46, XY, inv(7)(q11.2q22)c idiopathic thrombocytopenia q11.2 q22     9209470 III-4 son of 9209470_II-2 Edit
53 9209470_II-2 46, XX, inv(7)(q11.2q22)c acute myelomonocytic leukemia q11.2 q22     9209470 II-2 (case 1)   Edit
54 2340493_34 46, XX, ?inv(5) / 47, XX, +inv(7)(q11.2q32) / 47, idem, del(9)(q13)/ 46, XX [18/25] breast cancer q11.2 q32     2340493 MaCa 34 Mitelman Database, Reference No. 3377 Edit
55 2340493_39 47, XX, +inv(7)(q11.2q32) [1]/ 49, X -?X, +inv(7), +8, +9 [1]/ 46, XX [16] breast cancer q11.2 q32     2340493 MaCa 39 Mitelman Database, Reference No. 3377 Edit
56 7126479_A21 46, XY, del(5)(q13q31) [6]/ 46, XY, inv(7)(q13q32) [9]/ 46, XY [85] myelodysplastic syndrome q13 q32     7126479, 9973943 A21 Mitelman Database, Reference No. 848 Edit
57 12393284_ST95-479_2 46, XX, del(7)(q22q32)/ 46, XX, inv(7)(q21q22) uterine leiomyomata q21 q22     12393284 ST95-479   Edit
58 3476188_1 46, XY, del(11)(p12p15) [100%] [first relapse]
46, XY, inv(7)(q21q36), del(11)(p12p15) [80%]/ 46, idem, t(11;17)(q13;q25) [20%] [second relapse]
acute myelomonocytic leukemia - M4 q21 q36     3476188, 9973943 1 [3476188] Mitelman Database, Reference No. 2168 Edit
59 MCN_19940001-254 46, XX, inv(7)(q21.1q22.2) mat teratoma/ hamartoma q21.1 q22.2     MCN ID: 19940001-254 www.mcndb.org Edit
60 15630448 inv(7)(q21-22q34) thyroid carcinoma q21.2 q34 AKAP9 BRAF$ 15630448, 15630436   breakpoints lie in intron 8 of AKAP9 (q21.2) and intron 8 of BRAF (q34); Mitelman Database Reference No. 11160 Edit
61 8956866_23 46, XX, ?t(1;9;12)(q21;q21;p12), del(2)(p?10), del(3)(p?), add(4)(q?), -5, inv(7)(q22q36), del(10)(p11), t(19;?), add(21)(q?) [cp7] diffuse large B-cell lymphoma q22 q36     8956866 23 Mitelman Database, Reference No. 6667 Edit
62 6490390_10 46, XY, inv(7)(q22q36) Hodgkin's disease -> refractory anemia with excess of blasts q22 q36     6490390, 9973943 10 Mitelman Database, Reference No. 1083 Edit
63 6627222_184_1 46, XY, inv(7)(q22q36), t(15;17)(q22;q21.1) [75%]/ 46, XY, add(7)(q36), t(15;17) [13%]/ 2 single cell abnormalities acute promyelocytic leukemia - M3 q22 q36     6627222, 6586073, 9973943 184 Mitelman Database, Reference No. 1007 Edit
64 3730287_B 45, XY, add(2)(p25), dup(7)(q22q36), inv(9)(p11q13)c, -12/ 46, idem, +r acute megakaryoblastic leukemia - M7 q22 q36     3730287, 2790202 B [3730287], 9 in Table 5 [2790202]   Edit
65 ECACC_92102359 46, XY, inv(7)(q22.1q34) mat myelodysplasia q22.1 q34 rs6960789/ rs10279959 rs3801001/ rs12667738 8611680, 11328294 92102359 (cell line: DD1027) 190 bp (distal to distal inversion breakpoint and within rs12667738) was deleted; mother has inv(7); www.ecacc.or.uk Edit
66 8616020_43_2 47, XX, +8 [3]/47, idem, der(7)inv(7)(p11q31)del(7)(q31q33) [2]/ 43, X, -X, -6, -7, -19, +mar [3]/ 46, XX [2] myelodysplastic syndrome, acute myeloblastic leukemia - M2 q31 q33     8616020 43 Mitelman Database, Reference No. 6510 Edit
67 8464228_14 46, XY, add(2)(q34), del(6)(q16q24), inv(7)(q31q35), der(18)/ 46, XY, inv(7), add(9)(p24), inc acute myeloblastic leukemia - M2 q31 q35     8464228, 9973943 14 [8464228] Mitelman Database, Reference No. 4857 Edit